ACE inhibitor benazepril, captopril, enalapril, fosinopril, moexipril, perindopril, quinapril, ramipril, trandolapril. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy.
Lithium clearance may be decreased, increasing lithium concentrations and the risk of lithium toxicity. Lithium generally should not be given with diuretics. NDC 52427-43790 and bottles of 100 tablets NDC 52427-437-01. Ask your health care provider any questions you may have about how to use Prinzide.
What other drugs will affect hydrochlorothiazide and lisinopril Zestoretic? Impaired Renal Function: As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function may be anticipated in susceptible individuals. While the mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, lisinopril is antihypertensive even in patients with low-renin hypertension. Although lisinopril was antihypertensive in all races studied, black hypertensive patients usually a low-renin hypertensive population had a smaller average response to lisinopril monotherapy than nonblack patients.
When I took the first pill, I got a migraine and had to take a nap to try to sleep it off. When I awoke, I was nauseous and did vomit. I had to get my blood pressure down in one day to be able to have a tooth extracted which required a numbing drug to be administered to be able to remove the tooth. So, again I took another pill the following day before my dental appointment, and again I vomited and had a migraine. BUT, my blood pressure went down and I had the tooth removed. I won't take that drug again, though. And, with the tooth removed, my blood pressure is normal to slightly high. So, staying off the pills for now.
This may interfere with certain lab tests such as parathyroid function possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug. If you are using the liquid form of this medication, shake the bottle well before each dose. It is not known whether Lunesta will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. ACE is identical to kininase, an enzyme that degrades bradykinin. Whether increased levels of bradykinin, a potent vasodepressor peptide, play a role in the therapeutic effects of lisinopril remains to be elucidated. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use and wear protective clothing when outdoors. How should I take hydrochlorothiazide and lisinopril Zestoretic? This may occur at any time during treatment. ACE inhibitors have been associated with a higher rate of angioedema in black than in nonblack patients. Zestoretic should be promptly discontinued and the appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred. Even in those instances where swelling of only the tongue is involved, without respiratory distress, patients may require prolonged observation since treatment with antihistamines and corticosteroids may not be sufficient. Very rarely, fatalities have been reported due to angioedema associated with laryngeal edema or tongue edema. Patients with involvement of the tongue, glottis or larynx are likely to experience airway obstruction, especially those with a history of airway surgery. Lisinopril may not work as well in black patients. Contact your doctor if your symptoms do not improve or if they become worse. Keep your cool in hot environments. The antihypertensives effects may be enhanced in the postsympathectomy patient. Agents Increasing Serum Potassium: Lisinopril attenuates potassium loss caused by thiazide-type diuretics. Use of lisinopril with potassium-sparing diuretics eg, spironolactone, eplerenone, triamterene, or amiloride potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium. Therefore, if concomitant use of these agents is indicated, because of demonstrated hypokalemia, they should be used with caution and with frequent monitoring of serum potassium. Monitor and record BP and pulse.
Lisinopril may cause a dry, unproductive cough. If caused by lisinopril, this symptom usually stops after treatment with lisinopril is stopped. Further increases of either or both components should depend on clinical response with blood pressure measured at the interdosing interval to ensure that there is an adequate antihypertensive effect at that time. The hydrochlorothiazide dose should generally not be increased until 2-3 weeks have elapsed. After addition of the diuretic it may be possible to reduce the dose of lisinopril. This medication may interfere with certain lab tests such as parathyroid function possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug. If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.
Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney. NDC 52427-435-90 and bottles of 100 tablets NDC 52427-435-01. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. Hyperkalemia, hypokalemia, hypercalcemia, hypochloremic alkalosis, hyponatremia, and hypomagnesemia may occur. Hyperkalemia is more likely to occur in patients with renal impairment or diabetes, elderly patients, or severely ill patients. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma. Keep track of the amount of medicine used from each new bottle. Lunesta is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. Thiazides may decrease urinary calcium excretion. Thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism. Marked hypercalcemia may be evidence of hidden hyperparathyroidism. Thiazides should be discontinued before carrying out tests for parathyroid function. Prinzide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors. Lisinopril does not undergo metabolism and is excreted unchanged entirely in the urine. Based on urinary recovery, the mean extent of absorption of lisinopril is approximately 25 percent, with large intersubject variability 6%-60% at all doses tested 5-80 mg. Lisinopril absorption is not influenced by the presence of food in the gastrointestinal tract. Caution patients to avoid sudden position changes to prevent orthostatic hypotension and to lie or sit down if they experience dizziness or light-headedness when standing. Lunesta may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away Lunesta is against the law. Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. If this medication causes you to urinate more frequently, it is best to take it at least 4 hours before your bedtime to prevent having to get up to urinate.
This drug may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit beverages. Tell your doctor if your do not improve after 3 days of treatment or if your last more than 6 weeks. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Replacement Therapy: The combination may be substituted for the titrated individual components. Dehydration, electrolyte imbalance eg, hypokalemia, hypochloremia, hyponatremia hypotension. The antihypertensive effects of the drug may be enhanced in the postsympathectomy patient. Renal failure has been reported with cyclosporine and ACE inhibitor administration. If renal dysfunction occurs, it may be necessary to stop one or both agents. When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, discontinue therapy as soon as possible. Avoid sitting or standing without moving for prolonged periods of time. the legs decreases the effect of gravity, so swelling goes down. Additive or potentiation of hypotension effects.
If progressive renal impairment becomes evident consider withholding or discontinuing diuretic therapy. Anaphylactoid Reaction During Membrane Exposure. PREGNANCY and BREAST-FEEDING: Prinzide may cause birth defects and fetal or newborn death if you take it while you are pregnant. Do not become pregnant while you take Prinzide. If you think you may be pregnant, contact your doctor right away. Prinzide is found in breast milk. Do not breast-feed while taking Prinzide. Lisinopril should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed. Category D second and third trimesters; Category C first trimester. Lisinopril can cause fetal and neonatal morbidity and death when administered to pregnant women. Do not use during pregnancy. Overdose symptoms may include nausea, weakness, dizziness, dry mouth, thirst, muscle pain or weakness, or feeling like you might pass out. May cause decreased antihypertensive effects. Monitor BP closely. If BP control deteriorates, consider stopping ketorolac nasal. ZESTORETIC as soon as possible. If your symptoms do not improve or if they become worse, check with your doctor.
Some medical conditions may interact with lisinopril. Inform women of childbearing age about the consequences of exposure to ACE inhibitors during pregnancy. Advise patients to report pregnancies to their health care provider as soon as possible. Severe allergic reactions rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the hands, eyes, mouth, face, lips, or tongue; hoarseness; chest pain; decreased urination; irregular heartbeat; shortness of breath; stomach pain with or without nausea or vomiting; symptoms of infection eg, fever, chills, persistent sore throat; symptoms of liver problems eg, dark urine, loss of appetite, pale stools, yellowing of the skin or eyes; symptoms of low blood pressure eg, fainting, severe dizziness, light-headedness. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. In such patients renal function should be monitored during the first few weeks of therapy. Increases in BUN and serum creatinine may occur. May decrease renal excretion of potassium. Closely monitor serum potassium. Other drugs may interact with eszopiclone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. May cause excessive decreases in BP and syncope. Consider lower starting dosage of clozapine. Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist. In clinical studies, the extent of blood pressure reduction seen with the combination of lisinopril and hydrochlorothiazide was approximately additive. The Zestoretic 10-12.
For heart failure, some specific hawthorn products Faros 300 by Lichtwer Pharma, Crataegutt forte by Wilmer Schwabe Pharmaceuticals, or HeartCare, Nature's Way have been used in doses of 160 mg to 1800 mg divided and taken in 2-3 doses daily. These doses have been shown to improve symptoms of heart failure in some people, but they have also been shown to increase the risk of death or being hospitalized due to heart failure. In hypertensive patients with unilateral or bilateral renal artery stenosis, increases in blood urea nitrogen and serum creatinine may occur. Competitively inhibits ACE, preventing the conversion of angiotensin I to angiotensin II, reversing the potassium loss associated with the diuretic. Thiazides cross the placental barrier and appear in cord blood. This may not be a complete list of all interactions that may occur. Ask your health care provider if Prinzide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. It is unknown if lisinopril passes into breast milk. Hydrochlorothiazide passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. What happens if I overdose Zestoretic? In patients with renal disease, thiazides may precipitate azotemia.
Hydrochlorothiazide-induced electrolyte disturbances may predispose to digitalis-induced arrhythmias. Measure plasma concentrations of potassium and magnesium; supplement low levels. Prevent further losses with dietary management. Talk with your health provider. Drinking alcohol can further lower your blood pressure and may increase certain side effects of this medicine. Hydrochlorothiazide and lisinopril may also be used for purposes not listed in this medication guide. This medication passes into milk. Diabetes patients - Prinzide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
Skeletal muscle relaxants, nondepolarizing eg, tubocurarine - possible increased responsiveness to the muscle relaxant. Gold: Nitritoid reactions symptoms include facial flushing, nausea, vomiting and hypotension have been reported rarely in patients on therapy with injectable gold sodium aurothiomalate and concomitant ACE inhibitor therapy including Zestoretic. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Rest and protect a sore area. Stop, change, or take a break from any activity that may be causing your pain or soreness. Symptoms may include fainting; severe dizziness or light-headedness; symptoms of blood electrolyte problems eg, confusion; irregular heartbeat; mental or mood changes; muscle cramps, pain, or weakness; seizures; sluggishness; symptoms of dehydration eg, drowsiness; dry eyes; fast heartbeat; nausea; restlessness; unusual thirst, tiredness, or weakness; vomiting. Rarely, ACE inhibitors have been associated with a syndrome that starts with cholestatic jaundice and progresses to fulminant hepatic necrosis. This product may affect your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. Read the Patient Information Leaflet if available from your before you start taking this and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with do not feel sick. Ask your health care provider any questions you may have about how to use lisinopril. In rare cases, intestinal angioedema has been reported in post marketing experience. Tell your doctor or dentist that you take Prinzide before you receive any medical or dental care, emergency care, or surgery. You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril Lotensin captopril Capoten fosinopril Monopril enalapril Vasotec moexipril Univasc perindopril Aceon quinapril Accupril ramipril Altace or trandolapril Mavik. Hypotension - Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with lisinopril. The possibility of hypotensive effects with lisinopril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with lisinopril. Does Zestoretic oral have side effects? DNA breaks in an in vitro alkaline elution rat hepatocyte assay.
Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC. Potentiation of orthostatic hypotension may occur. Thiazides should be used with caution in severe renal disease. In patients with renal disease, thiazides may precipitate azotemia. Cumulative effects of the drug may develop in patients with impaired renal function. Lisinopril - In clinical trials adverse reactions which occurred with lisinopril were also seen with Zestoretic. What should I avoid while taking hydrochlorothiazide and lisinopril Zestoretic? Cough: See - Cough. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. The antihypertensive effects of lisinopril have continued during long-term therapy. Abrupt withdrawal of lisinopril has not been associated with a rapid increase in blood pressure; nor with a significant overshoot of pretreatment blood pressure. Hydrochlorothiazide is excreted by the kidneys and the risk of toxic reactions may be greater in patients with renal impairment. ZESTORETIC and other agents that affect the RAS. If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
After oral use diuresis begins within two hours, peaks in about four hours and lasts about 6 to 12 hours. Tablets - calcium phosphate, magnesium stearate, mannitol, red ferric oxide, starch, yellow ferric oxide. Talk to your doctor or about lifestyle changes that might benefit you. The sedative effects of Lunesta may be stronger in older adults. Accidental falls are common in elderly patients who take sedatives. Use caution to avoid falling or accidental injury while you are taking this medicine. Since Lunesta is taken only at bedtime, you will not be on a frequent dosing schedule. Never take this medicine if you do not have at least 7 to 8 hours to sleep before being active again. Do not take extra medicine to make up a missed dose. What happens if I overdose? Zestoretic is contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an angiotensin-converting enzyme inhibitor and in patients with hereditary or idiopathic angioedema. Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. Do not use this medication in children younger than 6 years unless directed by the doctor. If you are using the chewable tablets, do not use in children younger than 2 years unless directed by your doctor. Dizziness, lightheadedness, tiredness, or headache may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Swelling and pain are very common with injuries. When you have swelling, you should look for other symptoms of injury that may need to be evaluated by your doctor. The pharmacologic effects of both drugs may be increased. Hyperglycemia, hyperuricemia, and hypotension may occur. Closely monitor BP, blood glucose, and serum uric acid. Lisinopril may cause dizziness, light-headedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use lisinopril with caution. In clinical trials with Zestoretic no adverse experiences peculiar to this combination drug have been observed. Adverse experiences that have occurred have been limited to those that have been previously reported with lisinopril or hydrochlorothiazide. As a result of its diuretic effects, hydrochlorothiazide increases plasma renin activity, increases aldosterone secretion, and decreases serum potassium. Administration of lisinopril blocks the renin-angiotensin aldosterone axis and tends to reverse the potassium loss associated with the diuretic. If you miss a dose of lisinopril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Prinzide may cause a serious side effect called angioedema. Black patients may be at greater risk of developing this side effect. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Take Prinzide by mouth with or without food. Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension for example, patients with diabetes or hyperlipidemia and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal. Dosing considerations for Hawthorn. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Lisinopril is a prescription medication used to treat in both adults and children 6 years of age and older. Increases in cholesterol and triglyceride levels may be associated with thiazide diuretic therapy.
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Take each dose with a full glass of water. In a randomized, controlled comparison, the mean antihypertensive effects of Zestoretic 20-12. Similar considerations apply to patients with ischemic heart or cerebrovascular disease in whom an excessive fall in blood pressure could result in a myocardial infarction or cerebrovascular accident. Lab tests, including blood pressure, blood electrolyte levels, heart function, or kidney or liver function, may be performed while you use lisinopril. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
It is unknown if lisinopril passes into milk. This medicine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby. No specific information is available on the treatment of overdosage with Zestoretic. Treatment is symptomatic and supportive. Therapy with Zestoretic should be discontinued and the patient observed closely.
Concomitant administration of lisinopril and hydrochlorothiazide has little or no effect on the bioavailability of either drug. The combination tablet is bioequivalent to concomitant administration of the separate entities. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. If your doctor has prescribed this for you, not share it with others. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.
Treating high blood pressure alone or with other medicines. It is used along with other medicines to manage heart failure or improve survival after a heart attack. It may also be used for other conditions as determined by your doctor. Lisinopril was not mutagenic in the Ames microbial mutagen test with or without metabolic activation. It was also negative in a forward mutation assay using Chinese hamster lung cells. Lisinopril did not produce single strand DNA breaks in an in vitro alkaline elution rat hepatocyte assay. In addition, lisinopril did not produce increases in chromosomal aberrations in an in vitro test in Chinese hamster ovary cells or in an in vivo study in mouse bone marrow.